Constructive Bio
Constructive Bio is a synthetic biology company that rewrites genomes to create novel biomolecules, enabling next-generation materials and therapeutics beyond the limits of natural biology.
About
Constructive Bio rewrites the genome to build the biomolecules of the future. Its unique technology turns living cells into biofactories, creating sustainable new materials and therapeutics. With full control of the genetic sequence and code, the company is exploring chemical space previously unreached by natural biology.
Through exclusive access to breakthrough science from the MRC Laboratory of Molecular Biology, based on research carried out by founder Professor Jason Chin, Constructive Bio alone has the ability to rewrite entire genomes and incorporate multiple non-canonical amino acids in a single molecule.
Constructive Bio is realising the full scientific and commercial potential of its technologies through its proprietary platforms. These include:
Full genome synthesis: The company assembles DNA into genome-scale pieces, stitching and replacing megabases of DNA inside living cells. Through this process, it creates entirely new genomes from scratch, writing the genetic blueprint of cells with unprecedented flexibility and precision.
Engineered protein translation: Constructive Bio synthesises proteins with expanded functions by incorporating non-canonical amino acids (ncAAs). Through reprogramming the genetic code of cells and expanding their repertoire of chemical building blocks, its technology creates biofactories for the discovery and manufacturing of novel biopolymers. These molecules have unique properties and diverse applications across science and industry, including pharmaceuticals, agriculture, and biomaterials.
