Constructive Bio
Constructive Bio designs and manufactures proteins with chemistries that do not exist in nature.
About
Constructive Bio is expanding what biology can make. Its technology rewrites the genetic code so cells can incorporate new-to-nature chemical building blocks, giving partners a way to design proteins with properties that natural biology and conventional synthesis cannot reliably deliver.
At the centre of this work is BioForge, Constructive Bio’s programmable cellular manufacturing platform. BioForge turns advanced molecular designs into manufacturable products, including complex peptides, site-specific conjugates, covalent biologics, and oral therapeutics.
By connecting molecular design to scalable biological production, Constructive Bio helps its partners move from asking “can we make this?” to “what should we make next?”
Through exclusive access to breakthrough science from the MRC Laboratory of Molecular Biology, based on research carried out by founder Professor Jason Chin, Constructive Bio alone has the ability to rewrite entire genomes and incorporate multiple non-canonical amino acids in a single molecule.
Constructive Bio is realising the full scientific and commercial potential of its technologies through its proprietary platforms. These include:
Full genome synthesis: The company assembles DNA into genome-scale pieces, stitching and replacing megabases of DNA inside living cells. Through this process, it creates entirely new genomes from scratch, writing the genetic blueprint of cells with unprecedented flexibility and precision.
Engineered protein translation: Constructive Bio synthesises proteins with expanded functions by incorporating non-canonical amino acids (ncAAs). Through reprogramming the genetic code of cells and expanding their repertoire of chemical building blocks, its technology creates biofactories for the discovery and manufacturing of novel biopolymers. These molecules have unique properties and diverse applications across science and industry, including pharmaceuticals, agriculture, and biomaterials.
